Thermostable Endotoxin of Rickettsiae

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Morphological Structure of Rickettsiae

The morphological structures of the rickettsiae of epidemic and endemic typhus fever, Rocky Mountain spotted fever, and Q fever are similar to one another and to certain bacteria. The rickettsial organisms in common with the elementary bodies of vaccinia virus and all bacteria would appear to have a limiting membrane which surrounds a substance that seems to be protoplasmic in nature; numbers o...

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The Cytology of Rickettsiae

Internal structures of rickettsiae seen with phase contrast microscopy and in the electron microscope contain desoxyribonucleic acid and are therefore nuclear structures similar to those found in bacteria. They are minute spherical bodies, either single as in spherical rickettsiae or varying in number from 2 to 4 in rod-shaped forms. Occasional dumbbell-shaped chromatinic bodies are thought to ...

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Metabolic Studies of Rickettsiae

The present study is a continuation of our examination of the scope of intrinsic metabolic capacities of rickettsiae isolated from their host cells (Wisseman et al., 1951 and 1952). It is based on the following considerations: Bovarnick and Miller (1950) presented strong evidence for the presence of a glutamic-aspartic transaminase in Rickettsia prowazeki and Rickettsia mooseri, and some confir...

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Respiration of Typhus Rickettsiae

Partially purified suspensions of typhus rickettsiae have been shown to exhibit metabolic activity as evidenced by consumption of oxygen and production of carbon dioxide in the presence of glutamate. Similar activity at a much lower rate occurs in the presence of pyruvate. The rate of oxygen uptake was directly proportional to the concentration of viable rickettsiae, as estimated by their toxic...

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Tropism and Pathogenicity of Rickettsiae

Rickettsiae are obligate intracellular parasitic bacteria that cause febrile exanthematous illnesses such as Rocky Mountain spotted fever, Mediterranean spotted fever, epidemic, and murine typhus, etc. Although the vector ranges of each Rickettsia species are rather restricted; i.e., ticks belonging to Arachnida and lice and fleas belonging to Insecta usually act as vectors for spotted fever gr...

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ژورنال

عنوان ژورنال: Nature

سال: 1946

ISSN: 0028-0836,1476-4687

DOI: 10.1038/157552a0